FENTANYL OVERDOSES BY YEAR OPTIONS

Istradefylline forty mg/day increased peak levels and AUC of CYP3A4 substrates in clinical trials. This effect wasn't observed with istradefylline 20 mg/day. Consider dose reduction of sensitive CYP3A4 substrates.If coadministration of CYP3A4 inhibitors with fentanyl is important, watch patients for respiratory depression and sedation at Repeated i